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LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?
Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188135/ https://www.ncbi.nlm.nih.gov/pubmed/25339972 http://dx.doi.org/10.3389/fgene.2014.00338 |