Deep Sequencing Reveals Low Incidence of Endogenous LINE-1 Retrotransposition in Human Induced Pluripotent Stem Cells

Long interspersed element-1 (LINE-1 or L1) retrotransposition induces insertional mutations that can result in diseases. It was recently shown that the copy number of L1 and other retroelements is stable in induced pluripotent stem cells (iPSCs). However, by using an engineered reporter construct ov...

Descripción completa

Detalles Bibliográficos
Autores principales: Arokium, Hubert, Kamata, Masakazu, Kim, Sanggu, Kim, Namshin, Liang, Min, Presson, Angela P., Chen, Irvin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188539/
https://www.ncbi.nlm.nih.gov/pubmed/25289675
http://dx.doi.org/10.1371/journal.pone.0108682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188539/
https://www.ncbi.nlm.nih.gov/pubmed/25289675
http://dx.doi.org/10.1371/journal.pone.0108682

Ejemplares similares