Cargando…

Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect

We have recently reported that interferon gamma receptor deficient (IFNγR−/−) allogeneic donor T cells result in significantly less graft-versus-host disease (GvHD) than wild-type (WT) T cells, while maintaining an anti-leukemia or graft-versus-leukemia (GvL) effect after allogeneic hematopoietic st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Jaebok, Cooper, Matthew L., Alahmari, Bader, Ritchey, Julie, Collins, Lynne, Holt, Matthew, DiPersio, John F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188578/ https://www.ncbi.nlm.nih.gov/pubmed/25289677 http://dx.doi.org/10.1371/journal.pone.0109799

Ejemplares similares

Targeting IFNGR/IL6R or downstream JAK1/JAK2 to control GvHD
por: Ashami, Kidist, et al.
Publicado: (2018)

Editorial: Interferons and GvHD
por: Kim, Boram, et al.
Publicado: (2022)

Inflammasome effects in GvHD
por: Koehn, Brent H., et al.
Publicado: (2015)

Antibody- and aptamer-strategies for GvHD prevention
por: Oelkrug, Christopher, et al.
Publicado: (2015)

Established and Emerging Treatments of Skin GvHD
por: Link-Rachner, Cornelia S., et al.
Publicado: (2022)

Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD
por: Buxbaum, Nataliya P., et al.
Publicado: (2022)

Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation
por: Alahmari, Bader, et al.
Publicado: (2018)

The Role of Bacteria and Pattern Recognition Receptors in GvHD
por: Holler, E., et al.
Publicado: (2010)

Pathophysiology of GvHD and Other HSCT-Related Major Complications
por: Ghimire, Sakhila, et al.
Publicado: (2017)

New insights about immune populations in gastrointestinal GvHD
por: Hayase, Eiko, et al.
Publicado: (2023)

Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD)
por: Mhandire, Kudakwashe, et al.
Publicado: (2021)

Effects of immune system cells in GvHD and corresponding therapeutic strategies
por: Tavaf, Maryam Jadid, et al.
Publicado: (2023)

Bone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation
por: Szyska, Martin, et al.
Publicado: (2016)

CrkL is required for donor T cell migration to GvHD target organs
por: Roy, Nathan H., et al.
Publicado: (2020)

Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease
por: Choi, Jaebok, et al.
Publicado: (2018)

Insights into the role of the JAK/STAT signaling pathway in graft-versus-host disease
por: Abboud, Ramzi, et al.
Publicado: (2020)

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers
por: Li, Yan-Ruide, et al.
Publicado: (2022)

Antigen-Specific Priming is Dispensable in Depletion of Apoptosis-Sensitive T Cells for GvHD Prophylaxis
por: Yarkoni, Shai, et al.
Publicado: (2014)

Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells
por: Riegel, Christin, et al.
Publicado: (2019)

Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Roberto, Crocchiolo, et al.
Publicado: (2021)

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
por: Bojanic, Ines, et al.
Publicado: (2023)

Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases
por: Wernicke, Caroline M, et al.
Publicado: (2011)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
por: Crocchiolo, Roberto, et al.
Publicado: (2021)

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions
por: Monzavi, Seyed Mostafa, et al.
Publicado: (2022)

Accumulation of T-cell-suppressive PD-L1(high) extracellular vesicles is associated with GvHD and might impact GvL efficacy
por: Baur, Rebecca, et al.
Publicado: (2023)

The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview
por: Boieri, Margherita, et al.
Publicado: (2016)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
por: Ryu, Jaeyoon, et al.
Publicado: (2020)

Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
por: Greco, Raffaella, et al.
Publicado: (2019)

Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD
por: Bruce, Danny W., et al.
Publicado: (2021)

Tacrolimus initial steady state level in post-transplant cyclophosphamide based GvHD prophylaxis regimens
por: Yao, Janny M., et al.
Publicado: (2022)

Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome
por: Reschke, Robin, et al.
Publicado: (2022)

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
por: Shaikh, Haroon, et al.
Publicado: (2022)

Extracorporeal Photopheresis (ECP) and the Potential of Novel Biomarkers in Optimizing Management of Acute and Chronic Graft vs. Host Disease (GvHD)
por: Mankarious, Matthew, et al.
Publicado: (2020)

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion
por: Chopra, Martin, et al.
Publicado: (2016)

The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD Following Hematopoietic Stem Cell Transplantation
por: Mousavi, Seyed Asadollah, et al.
Publicado: (2017)

Evidence for CD19B–CD8T cell interactions in blood and tissues from patients with GvHD
por: Deola, S, et al.
Publicado: (2017)

Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study
por: Boberg, Erik, et al.
Publicado: (2020)

(18)F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)
por: Roll, Wolfgang, et al.
Publicado: (2021)

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
por: Ghimire, Sakhila, et al.
Publicado: (2021)

Burden and Needs of Patients with Severe GvHD from the Supportive and Palliative Care Perspective—A Literature Review
por: Wenzel, Freya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r3q6rj3ktpilhgeq6hcvsj9nt1