Break CDK2/Cyclin E1 Interface Allosterically with Small Peptides

Most inhibitors of Cyclin-dependent kinase 2 (CDK2) target its ATP-binding pocket. It is difficult, however, to use this pocket to design very specific inhibitors because this catalytic pocket is highly conserved in the protein family of CDKs. Here we report some short peptides targeting a noncataly...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Zhao, Yunjie, Li, Haotian, Zhang, Dongyan, Huang, Yanzhao, Shen, Qi, Van Duyne, Rachel, Kashanchi, Fatah, Zeng, Chen, Liu, Shiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188581/
https://www.ncbi.nlm.nih.gov/pubmed/25290691
http://dx.doi.org/10.1371/journal.pone.0109154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188581/
https://www.ncbi.nlm.nih.gov/pubmed/25290691
http://dx.doi.org/10.1371/journal.pone.0109154

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