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Break CDK2/Cyclin E1 Interface Allosterically with Small Peptides
Most inhibitors of Cyclin-dependent kinase 2 (CDK2) target its ATP-binding pocket. It is difficult, however, to use this pocket to design very specific inhibitors because this catalytic pocket is highly conserved in the protein family of CDKs. Here we report some short peptides targeting a noncataly...
Autores principales: | Chen, Hao, Zhao, Yunjie, Li, Haotian, Zhang, Dongyan, Huang, Yanzhao, Shen, Qi, Van Duyne, Rachel, Kashanchi, Fatah, Zeng, Chen, Liu, Shiyong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188581/ https://www.ncbi.nlm.nih.gov/pubmed/25290691 http://dx.doi.org/10.1371/journal.pone.0109154 |
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