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Autonomous Stimulation of Cancer Cell Plasticity by the Human NKG2D Lymphocyte Receptor Coexpressed with Its Ligands on Cancer Cells
The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors counteract by employing tactics to disable lymphocyte NKG2D. This negative dynamic is escalated as some human cancer cells co-opt expression o...
Autores principales: | Cai, Xin, Dai, Zhenpeng, Reeves, Rebecca S., Caballero-Benitez, Andrea, Duran, Kate L., Delrow, Jeffrey J., Porter, Peggy L., Spies, Thomas, Groh, Veronika |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188595/ https://www.ncbi.nlm.nih.gov/pubmed/25291178 http://dx.doi.org/10.1371/journal.pone.0108942 |
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