Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(...

Descripción completa

Detalles Bibliográficos
Autores principales: Usenko, Tatiana, Chan, Gordon, Torlakovic, Emina, Klingmüller, Ursula, Neel, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188809/
https://www.ncbi.nlm.nih.gov/pubmed/25289670
http://dx.doi.org/10.1371/journal.pone.0109682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188809/
https://www.ncbi.nlm.nih.gov/pubmed/25289670
http://dx.doi.org/10.1371/journal.pone.0109682

Ejemplares similares