Evaluation of the genotoxicity of ginseng leaf extract UG0712

Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to allow for its clinical use. We evaluated the genotoxicity of UG0712, which is a p...

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Autores principales: Kim, Ji-Young, Ri, Yu, Do, Seon-Gil, Lee, Young-Chul, Park, Sang-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188829/
https://www.ncbi.nlm.nih.gov/pubmed/25324871
http://dx.doi.org/10.5625/lar.2014.30.3.104
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author Kim, Ji-Young
Ri, Yu
Do, Seon-Gil
Lee, Young-Chul
Park, Sang-Joon
author_facet Kim, Ji-Young
Ri, Yu
Do, Seon-Gil
Lee, Young-Chul
Park, Sang-Joon
author_sort Kim, Ji-Young
collection PubMed
description Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to allow for its clinical use. We evaluated the genotoxicity of UG0712, which is a powdered extract of ginseng leaves. UG0712 did not increase the number of revertant colonies in 4 histidine auxotrophic strains of Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) or in a tryptophan auxotrophic strain of Escherichia coli (WP2uvrA(pKM101)) at any concentration evaluated, either in the absence or presence of the metabolic activation system. There was no significant increase in the number of metaphase cells with structural or numerical aberrations in the UG0712-treated groups compared to the concurrent vehicle control at any dose, regardless of the presence of the metabolic activation system. Oral administration of the extract at doses up to 2,000 mg/kg in male mice did not increase the frequency of micronucleated polychromatic erythrocytes in the bone marrow, and did not result in any significant clinical signs, body weight loss, gross findings, or mortality. These results suggest that UG0712 does not act as a mutagenic or genotoxic material at the concentrations evaluated.
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spelling pubmed-41888292014-10-16 Evaluation of the genotoxicity of ginseng leaf extract UG0712 Kim, Ji-Young Ri, Yu Do, Seon-Gil Lee, Young-Chul Park, Sang-Joon Lab Anim Res Original Article Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to allow for its clinical use. We evaluated the genotoxicity of UG0712, which is a powdered extract of ginseng leaves. UG0712 did not increase the number of revertant colonies in 4 histidine auxotrophic strains of Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) or in a tryptophan auxotrophic strain of Escherichia coli (WP2uvrA(pKM101)) at any concentration evaluated, either in the absence or presence of the metabolic activation system. There was no significant increase in the number of metaphase cells with structural or numerical aberrations in the UG0712-treated groups compared to the concurrent vehicle control at any dose, regardless of the presence of the metabolic activation system. Oral administration of the extract at doses up to 2,000 mg/kg in male mice did not increase the frequency of micronucleated polychromatic erythrocytes in the bone marrow, and did not result in any significant clinical signs, body weight loss, gross findings, or mortality. These results suggest that UG0712 does not act as a mutagenic or genotoxic material at the concentrations evaluated. Korean Association for Laboratory Animal Science 2014-09 2014-09-29 /pmc/articles/PMC4188829/ /pubmed/25324871 http://dx.doi.org/10.5625/lar.2014.30.3.104 Text en Copyright © 2014 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Ji-Young
Ri, Yu
Do, Seon-Gil
Lee, Young-Chul
Park, Sang-Joon
Evaluation of the genotoxicity of ginseng leaf extract UG0712
title Evaluation of the genotoxicity of ginseng leaf extract UG0712
title_full Evaluation of the genotoxicity of ginseng leaf extract UG0712
title_fullStr Evaluation of the genotoxicity of ginseng leaf extract UG0712
title_full_unstemmed Evaluation of the genotoxicity of ginseng leaf extract UG0712
title_short Evaluation of the genotoxicity of ginseng leaf extract UG0712
title_sort evaluation of the genotoxicity of ginseng leaf extract ug0712
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188829/
https://www.ncbi.nlm.nih.gov/pubmed/25324871
http://dx.doi.org/10.5625/lar.2014.30.3.104
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