Cargando…

In vivo P-glycoprotein function before and after epilepsy surgery

OBJECTIVES: To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure freq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauer, Martin, Karch, Rudolf, Zeitlinger, Markus, Liu, Joan, Koepp, Matthias J., Asselin, Marie-Claude, Sisodiya, Sanjay M., Hainfellner, Johannes A., Wadsak, Wolfgang, Mitterhauser, Markus, Müller, Markus, Pataraia, Ekaterina, Langer, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189097/ https://www.ncbi.nlm.nih.gov/pubmed/25186858 http://dx.doi.org/10.1212/WNL.0000000000000858

Ejemplares similares

A PET microdosing study with the P-glycoprotein inhibitor tariquidar
por: Bauer, Martin, et al.
Publicado: (2012)

Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[(11)C]verapamil PET study
por: Bauer, Martin, et al.
Publicado: (2015)

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[(11)C]verapamil PET
por: Bauer, Martin, et al.
Publicado: (2010)

[(11)C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans
por: Bauer, Martin, et al.
Publicado: (2011)

Decreased blood-brain barrier P-glycoprotein function with aging
por: Bauer, Martin, et al.
Publicado: (2008)

Imaging Biomarkers or Biomarker Imaging?
por: Mitterhauser, Markus, et al.
Publicado: (2014)

Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography
por: Wulkersdorfer, Beatrix, et al.
Publicado: (2019)

A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of (11)C- and (14)C-labelled verapamil in healthy volunteers
por: Wagner, Claudia C, et al.
Publicado: (2008)

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography
por: Hernández Lozano, Irene, et al.
Publicado: (2019)

Utility of Absolute Quantification in Non-lesional Extratemporal Lobe Epilepsy Using FDG PET/MR Imaging
por: Traub-Weidinger, Tatjana, et al.
Publicado: (2020)

Pharmacokinetic Imaging with Radiolabeled Molecularly Targeted Anticancer Drugs
por: Bauer, Martin, et al.
Publicado: (2020)

Prospective evaluation of the performance of [(68)Ga]Ga-PSMA-11 PET/CT(MRI) for lymph node staging in patients undergoing superextended salvage lymph node dissection after radical prostatectomy
por: Abufaraj, Mohammad, et al.
Publicado: (2019)

New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics
por: Zeilinger, Markus, et al.
Publicado: (2017)

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
por: Shanab, Karem, et al.
Publicado: (2014)

Binding Affinity of Some Endogenous and Synthetic TSPO Ligands Regarding the rs6971 Polymorphism
por: Berroterán-Infante, Neydher, et al.
Publicado: (2019)

The value of [(11)C]-acetate PET and [(18)F]-FDG PET in hepatocellular carcinoma before and after treatment with transarterial chemoembolization and bevacizumab
por: Li, Shuren, et al.
Publicado: (2017)

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure
por: El Biali, Myriam, et al.
Publicado: (2021)

Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [(11)C]Metoclopramide
por: Bauer, Martin, et al.
Publicado: (2021)

Comparison of fully-automated radiosyntheses of [(11)C]erlotinib for preclinical and clinical use starting from in target produced [(11)C]CO(2) or [(11)C]CH(4)
por: Philippe, Cécile, et al.
Publicado: (2018)

Dissimilar Effect of P-Glycoprotein and Breast Cancer Resistance Protein Inhibition on the Distribution of Erlotinib to the Retina and Brain in Humans and Mice
por: Biali, Myriam El, et al.
Publicado: (2023)

[(18)F]FMeNER-D2: Reliable fully-automated synthesis for visualization of the norepinephrine transporter
por: Rami-Mark, Christina, et al.
Publicado: (2013)

Development and evaluation of a rapid analysis for HEPES determination in (68)Ga-radiotracers
por: Pfaff, Sarah, et al.
Publicado: (2018)

[(18)F]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents
por: Haeusler, Daniela, et al.
Publicado: (2015)

Preparation and First Preclinical Evaluation of [(18)F]FE@SNAP: A Potential PET Tracer for the Melanin-Concentrating Hormone Receptor-1 (MCHR1)
por: Philippe, Cécile, et al.
Publicado: (2013)

[(18)F]FE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?
por: Philippe, Cécile, et al.
Publicado: (2016)

PM478. Imaging the effects of d-amphetamine in the human brain for modelling dopaminergic alterations in schizophrenia
por: Willeit, Matthäus, et al.
Publicado: (2016)

Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [(11)C]SNAP-7941 and [(18)F]FE@SNAP for Positron Emission Tomography
por: Schirmer, Eva, et al.
Publicado: (2013)

Pharmacogenomics in epilepsy
por: Balestrini, Simona, et al.
Publicado: (2018)

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People
por: Kranz, Georg S., et al.
Publicado: (2015)

In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [(11)C]SNAP-7941 and [(18)F]FE@SNAP reveal specific uptake in the ventricular system
por: Zeilinger, Markus, et al.
Publicado: (2017)

Brain glucose uptake during transcranial direct current stimulation measured with functional [(18)F]FDG-PET
por: Kraus, Christoph, et al.
Publicado: (2019)

Prospective non-invasive evaluation of CXCR4 expression for the diagnosis of MALT lymphoma using [(68)Ga]Ga-Pentixafor-PET/MRI
por: Haug, Alexander R., et al.
Publicado: (2019)

Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy
por: Vanicek, Thomas, et al.
Publicado: (2016)

Effects of Silexan on the Serotonin-1A Receptor and Microstructure of the Human Brain: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study with Molecular and Structural Neuroimaging
por: Baldinger, Pia, et al.
Publicado: (2015)

Clinical outcome of standardized (177)Lu-PSMA-617 therapy in metastatic prostate cancer patients receiving 7400 MBq every 4 weeks
por: Rasul, Sazan, et al.
Publicado: (2019)

Synthesis and in Silico Evaluation of Novel Compounds for PET-Based Investigations of the Norepinephrine Transporter
por: Neudorfer, Catharina, et al.
Publicado: (2015)

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study
por: Thom, Maria, et al.
Publicado: (2011)

Association of dopamine D(2/3) receptor binding potential measured using PET and [(11)C]-(+)-PHNO with post-mortem DRD(2/3) gene expression in the human brain
por: Komorowski, Arkadiusz, et al.
Publicado: (2020)

**-Postprandial pancreatic [(11)C]methionine uptake after pancreaticoduodenectomy mirrors basal beta cell function and insulin release
por: Steiner, Emanuel, et al.
Publicado: (2016)

Neuropathology of 16p13.11 Deletion in Epilepsy
por: Liu, Joan Y. W., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_r267o04odb0ftclrk2nfpb6jcq