Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

Abnormal accumulation of filamentous α-synuclein (α-syn) in neurons, regarded as Lewy bodies (LBs), are a hallmark of Parkinson disease (PD). Although the exact mechanism(s) underlying LBs formation remains unknown, autophagy and ER stress response have emerged as two important pathways affecting α-...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Peizhou, Gan, Ming, Lin, Wen-Lang, Yen, Shu-Hui C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189422/
https://www.ncbi.nlm.nih.gov/pubmed/25339898
http://dx.doi.org/10.3389/fnagi.2014.00268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189422/
https://www.ncbi.nlm.nih.gov/pubmed/25339898
http://dx.doi.org/10.3389/fnagi.2014.00268

Ejemplares similares