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Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

Abnormal accumulation of filamentous α-synuclein (α-syn) in neurons, regarded as Lewy bodies (LBs), are a hallmark of Parkinson disease (PD). Although the exact mechanism(s) underlying LBs formation remains unknown, autophagy and ER stress response have emerged as two important pathways affecting α-...

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Detalles Bibliográficos
Autores principales:	Jiang, Peizhou, Gan, Ming, Lin, Wen-Lang, Yen, Shu-Hui C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189422/ https://www.ncbi.nlm.nih.gov/pubmed/25339898 http://dx.doi.org/10.3389/fnagi.2014.00268

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