Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase

In this review, information regarding substrate and site specificities, catalytic mechanism, and protonation states of the catalytic Asp dyad of β-secretase (BACE1) derived from computational studies has been discussed. BACE1 catalyzes the rate-limiting step in the generation of Alzheimer amyloid be...

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Detalles Bibliográficos
Autores principales: Barman, Arghya, Prabhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189502/
https://www.ncbi.nlm.nih.gov/pubmed/25309776
http://dx.doi.org/10.1155/2014/598728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189502/
https://www.ncbi.nlm.nih.gov/pubmed/25309776
http://dx.doi.org/10.1155/2014/598728

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