Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Mingjin, Li, Jing, Peng, Qiuxian, Liu, Yi, Liu, Wei, Luo, Chaohua, Peng, Ju, Li, Junkui, Yung, Ken Kin Lam, Mo, Zhixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189683/
https://www.ncbi.nlm.nih.gov/pubmed/25256700
http://dx.doi.org/10.1186/s12974-014-0167-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189683/
https://www.ncbi.nlm.nih.gov/pubmed/25256700
http://dx.doi.org/10.1186/s12974-014-0167-6

Ejemplares similares