A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo

Instability of targeting ligand is a roadblock towards successful development of folate targeted liposomes. Folate ligands have been linked to polyethylene glycol (PEG) and cholesterol by an amide bond to form folate-CONH-PEG-CONH-Cholesterol (F-CONH-PEG-CONH-Chol), which is subject to hydrolysis. T...

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Detalles Bibliográficos
Autores principales: Huang, Yifei, Yang, Tan, Zhang, Wendian, Lu, Yao, Ye, Peng, Yang, Guang, Li, Bin, Qi, Shibo, Liu, Yong, He, Xingxing, Lee, Robert J, Xu, Chuanrui, Xiang, Guangya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189705/
https://www.ncbi.nlm.nih.gov/pubmed/25302024
http://dx.doi.org/10.2147/IJN.S69115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189705/
https://www.ncbi.nlm.nih.gov/pubmed/25302024
http://dx.doi.org/10.2147/IJN.S69115

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