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Structure of cohesin subcomplex pinpoints direct shugoshin–Wapl antagonism in centromeric cohesion
Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its protector sororin, triggering Wapl-dependent cohesin release from chromosome arms. The shugoshin (Sgo1)–PP2A complex protect...
Autores principales: | Hara, Kodai, Zheng, Ge, Qu, Qianhui, Liu, Hong, Ouyang, Zhuqing, Chen, Zhe, Tomchick, Diana R., Yu, Hongtao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190070/ https://www.ncbi.nlm.nih.gov/pubmed/25173175 http://dx.doi.org/10.1038/nsmb.2880 |
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