Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules including cytokines. The remodeling of the ECM by heparanase is important for various physiological and pathological processes,...

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Detalles Bibliográficos
Autores principales: Goodall, Katharine J., Poon, Ivan K. H., Phipps, Simon, Hulett, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190175/
https://www.ncbi.nlm.nih.gov/pubmed/25295599
http://dx.doi.org/10.1371/journal.pone.0109596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190175/
https://www.ncbi.nlm.nih.gov/pubmed/25295599
http://dx.doi.org/10.1371/journal.pone.0109596

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