Cargando…

Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice

The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Škrnjug, Ivana, Guzmán, Carlos Alberto, Ruecker, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190368/ https://www.ncbi.nlm.nih.gov/pubmed/25295996 http://dx.doi.org/10.1371/journal.pone.0110150

Ejemplares similares

Correction: Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
Publicado: (2015)

The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages
por: Škrnjug, Ivana, et al.
Publicado: (2014)

Ultrastructural localization of cyclic GMP and cyclic AMP in rat striatum
Publicado: (1981)

Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets
por: Kleppe, Rune, et al.
Publicado: (2018)

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo
por: Blaauboer, Steven M, et al.
Publicado: (2015)

Crystal structure and functional implication of a bacterial cyclic AMP–AMP–GMP synthetase
por: Ko, Tzu-Ping, et al.
Publicado: (2021)

Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae
por: Severin, Geoffrey B., et al.
Publicado: (2018)

Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture
por: Mayer, Alice, et al.
Publicado: (2017)

CRP-Cyclic AMP Regulates the Expression of Type 3 Fimbriae via Cyclic di-GMP in Klebsiella pneumoniae
por: Lin, Ching-Ting, et al.
Publicado: (2016)

Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
por: Ruksakiet, Kasidid, et al.
Publicado: (2021)

Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
por: Gao, Juyi, et al.
Publicado: (2015)

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
por: Sharma, Manish, et al.
Publicado: (2020)

Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture
por: Mayer, Alice, et al.
Publicado: (2017)

Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP—AMP to control predation in Bdellovibrio bacteriovorus
por: Rangarajan, Aathmaja Anandhi, et al.
Publicado: (2022)

Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP–AMP Synthase (cGAS) Deficient Mice
por: Visitchanakun, Peerapat, et al.
Publicado: (2021)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses
por: Pépin, Geneviève, et al.
Publicado: (2017)

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes
por: Wang, Yan, et al.
Publicado: (2015)

Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase
por: Sato, Hiroki, et al.
Publicado: (2021)

Immature lung TNFR2(−) conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
por: Mansouri, Samira, et al.
Publicado: (2018)

The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition
por: Hall, Justin, et al.
Publicado: (2017)

The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion
por: Hu, Tongyu, et al.
Publicado: (2021)

Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
por: Guo, Xin, et al.
Publicado: (2017)

DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
por: Parvatiyar, Kislay, et al.
Publicado: (2012)

DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31
por: Li, Fengyang, et al.
Publicado: (2019)

Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides
por: Werner, Katharina, et al.
Publicado: (2011)

Quantification of cAMP and cGMP analogs in intact cells: pitfals in enzyme immunoassays for cyclic nucleotides
por: Werner, Katharina, et al.
Publicado: (2011)

The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation
por: Bhattacharya, Madhurima, et al.
Publicado: (2023)

Effect of Ca2+, cyclic GMP, and cyclic AMP added to artificial solution perfusing lingual artery on frog gustatory nerve responses
Publicado: (1982)

It's cold, mom! It's cyclic GMP
por: Kuhn, Michaela
Publicado: (2015)

Cyclic GMP and Cilia Motility
por: Wyatt, Todd A.
Publicado: (2015)

A study of Chitosan and c‐di‐GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine
por: Svindland, Signe C., et al.
Publicado: (2012)

Antitumor Trans Platinum Adducts of GMP and AMP
por: Liu, Yangzhong, et al.
Publicado: (2000)

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
por: Onyedibe, Kenneth I., et al.
Publicado: (2021)

The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis
por: Liu, Yuliang, et al.
Publicado: (2022)

Gating by Cyclic Gmp and Voltage in the α Subunit of the Cyclic Gmp–Gated Channel from Rod Photoreceptors
por: Benndorf, Klaus, et al.
Publicado: (1999)

Role of cGMP and cAMP in the hemodynamic response to intrathecal sildenafil administration
por: Bombarda, Gabriela, et al.
Publicado: (2011)

Activation of cGMP-dependent protein kinase Iα and cAMP-dependent protein kinase A isoforms by cyclic nucleotides
por: Wolter, Sabine, et al.
Publicado: (2011)

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor
por: Ozasa, Koji, et al.
Publicado: (2019)

Cyclic GMP–AMP Synthase (cGAS) Deletion Reduces Severity in Bilateral Nephrectomy Mice through Changes in Neutrophil Extracellular Traps and Mitochondrial Respiration
por: Suksawad, Nattavong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8jhhdh3burkl0qe1hs1qpohl1a