Acylation of Glucagon-Like Peptide-2: Interaction with Lipid Membranes and In Vitro Intestinal Permeability

BACKGROUND: Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation as well as increasing enzymatic stability without disrupting biological potency. Acylation has furthermore been shown to increase interactions with the lipid membranes of mammalian...

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Detalles Bibliográficos
Autores principales: Trier, Sofie, Linderoth, Lars, Bjerregaard, Simon, Andresen, Thomas Lars, Rahbek, Ulrik Lytt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190408/
https://www.ncbi.nlm.nih.gov/pubmed/25295731
http://dx.doi.org/10.1371/journal.pone.0109939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190408/
https://www.ncbi.nlm.nih.gov/pubmed/25295731
http://dx.doi.org/10.1371/journal.pone.0109939

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