A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

BACKGROUND: Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most lethal cancers and often associated with a high accumulation of ROS. Recent stu...

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Detalles Bibliográficos
Autores principales: Cheng, Xinlai, Holenya, Palvo, Can, Suzan, Alborzinia, Hamed, Rubbiani, Riccardo, Ott, Ingo, Wölfl, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190468/
https://www.ncbi.nlm.nih.gov/pubmed/25253202
http://dx.doi.org/10.1186/1476-4598-13-221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190468/
https://www.ncbi.nlm.nih.gov/pubmed/25253202
http://dx.doi.org/10.1186/1476-4598-13-221

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