Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics

BACKGROUND: The HIV-1 envelope glycoprotein (Env) undergoes conformational changes that mediate fusion between virus and host cell membranes. These changes involve transient exposure of two heptad-repeat domains (HR1 and HR2) in the gp41 subunit and their subsequent self-assembly into a six-helix bu...

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Detalles Bibliográficos
Autores principales: De Feo, Christopher J, Wang, Wei, Hsieh, Meng-Lun, Zhuang, Min, Vassell, Russell, Weiss, Carol D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190581/
https://www.ncbi.nlm.nih.gov/pubmed/25274545
http://dx.doi.org/10.1186/s12977-014-0086-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190581/
https://www.ncbi.nlm.nih.gov/pubmed/25274545
http://dx.doi.org/10.1186/s12977-014-0086-8

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