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Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics

BACKGROUND: The HIV-1 envelope glycoprotein (Env) undergoes conformational changes that mediate fusion between virus and host cell membranes. These changes involve transient exposure of two heptad-repeat domains (HR1 and HR2) in the gp41 subunit and their subsequent self-assembly into a six-helix bu...

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Detalles Bibliográficos
Autores principales:	De Feo, Christopher J, Wang, Wei, Hsieh, Meng-Lun, Zhuang, Min, Vassell, Russell, Weiss, Carol D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190581/ https://www.ncbi.nlm.nih.gov/pubmed/25274545 http://dx.doi.org/10.1186/s12977-014-0086-8

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