AMPK-TAB1 activated p38 drives human T cell senescence

In T lymphocytes, p38 MAP kinase (MAPK) regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative T cell receptor (TCR) activation pathway. Here we show that senescent human T cells lack the canonical and alternative pathways of p38 activation, but spontaneously...

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Detalles Bibliográficos
Autores principales: Lanna, Alessio, Henson, Sian M., Escors, David, Akbar, Arne N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190666/
https://www.ncbi.nlm.nih.gov/pubmed/25151490
http://dx.doi.org/10.1038/ni.2981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190666/
https://www.ncbi.nlm.nih.gov/pubmed/25151490
http://dx.doi.org/10.1038/ni.2981

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