Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

Background: Haptoglobin (Hp) prevents hemoglobin (Hb) extravasation and attenuates Hb induced tissue oxidation and vasoconstriction. Small animal models such as mouse, rat and guinea pig appear to demonstrate proof-of-concept for Hb neutralization by Hp in diverse pre-clinical conditions. However, t...

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Detalles Bibliográficos
Autores principales: Boretti, Felicitas S., Baek, Jin Hyen, Palmer, Andre F., Schaer, Dominik J., Buehler, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191077/
https://www.ncbi.nlm.nih.gov/pubmed/25346694
http://dx.doi.org/10.3389/fphys.2014.00385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191077/
https://www.ncbi.nlm.nih.gov/pubmed/25346694
http://dx.doi.org/10.3389/fphys.2014.00385

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