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Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications
Background: Haptoglobin (Hp) prevents hemoglobin (Hb) extravasation and attenuates Hb induced tissue oxidation and vasoconstriction. Small animal models such as mouse, rat and guinea pig appear to demonstrate proof-of-concept for Hb neutralization by Hp in diverse pre-clinical conditions. However, t...
Autores principales: | Boretti, Felicitas S., Baek, Jin Hyen, Palmer, Andre F., Schaer, Dominik J., Buehler, Paul W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191077/ https://www.ncbi.nlm.nih.gov/pubmed/25346694 http://dx.doi.org/10.3389/fphys.2014.00385 |
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