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The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes
Chromatin constitutes a repressive barrier to the process of ligand-dependent transcriptional activity of nuclear receptors. Nucleosomes prevent the binding of estrogen receptor α (ERα) in absence of ligand and thus represent an important level of transcriptional regulation. Here, we show that in br...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191390/ https://www.ncbi.nlm.nih.gov/pubmed/25223786 http://dx.doi.org/10.1093/nar/gku791 |