Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence

Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are routinely used to treat HIV-1 infection, yet their mechanism of action remains unclear despite intensive investigation. In this study, we developed complementary single-molecule fluorescence and ensemble fluorescence anisotropy approa...

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Detalles Bibliográficos
Autores principales: Schauer, Grant D., Huber, Kelly D., Leuba, Sanford H., Sluis-Cremer, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191400/
https://www.ncbi.nlm.nih.gov/pubmed/25232099
http://dx.doi.org/10.1093/nar/gku819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191400/
https://www.ncbi.nlm.nih.gov/pubmed/25232099
http://dx.doi.org/10.1093/nar/gku819

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