Structural and energetic characterization of the major DNA adduct formed from the food mutagen ochratoxin A in the NarI hotspot sequence: influence of adduct ionization on the conformational preferences and implications for the NER propensity

The nephrotoxic food mutagen ochratoxin A (OTA) produces DNA adducts in rat kidneys, the major lesion being the C8-linked-2′-deoxyguanosine adduct (OTB-dG). Although research on other adducts stresses the importance of understanding the structure of the associated adducted DNA, site-specific incorpo...

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Detalles Bibliográficos
Autores principales: Sharma, Purshotam, Manderville, Richard A., Wetmore, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191402/
https://www.ncbi.nlm.nih.gov/pubmed/25217592
http://dx.doi.org/10.1093/nar/gku821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191402/
https://www.ncbi.nlm.nih.gov/pubmed/25217592
http://dx.doi.org/10.1093/nar/gku821

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