Cargando…

Structural and energetic characterization of the major DNA adduct formed from the food mutagen ochratoxin A in the NarI hotspot sequence: influence of adduct ionization on the conformational preferences and implications for the NER propensity

The nephrotoxic food mutagen ochratoxin A (OTA) produces DNA adducts in rat kidneys, the major lesion being the C8-linked-2′-deoxyguanosine adduct (OTB-dG). Although research on other adducts stresses the importance of understanding the structure of the associated adducted DNA, site-specific incorpo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Purshotam, Manderville, Richard A., Wetmore, Stacey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191402/ https://www.ncbi.nlm.nih.gov/pubmed/25217592 http://dx.doi.org/10.1093/nar/gku821

Ejemplares similares

Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity
por: Sproviero, Michael, et al.
Publicado: (2014)

Adenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen–purine linkage in the differential global genomic repair propensity
por: Kathuria, Preetleen, et al.
Publicado: (2015)

Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence
por: Jain, Vipin, et al.
Publicado: (2012)

Structure and stability of DNA containing an aristolactam II-dA lesion: implications for the NER recognition of bulky adducts
por: Lukin, Mark, et al.
Publicado: (2012)

C-Linked 8-aryl guanine nucleobase adducts: biological outcomes and utility as fluorescent probes
por: Manderville, Richard A., et al.
Publicado: (2016)

Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA
por: Jennings-Gee, Jamie E., et al.
Publicado: (2010)

Solution structure of DNA containing α-OH-PdG: the mutagenic adduct produced by acrolein
por: Zaliznyak, Tanya, et al.
Publicado: (2009)

Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N(2)-dG adduct in the NarI DNA recognition sequence
por: Stavros, Kallie M., et al.
Publicado: (2014)

Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System
por: Naumenko, N. V., et al.
Publicado: (2022)

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots
por: Liapis, Evagelos, et al.
Publicado: (2008)

Base-Displaced Intercalated Conformation of the 2-Amino-3-methylimidazo[4,5-f]quinoline N(2)-dG DNA Adduct Positioned at the Nonreiterated G(1) in the NarI Restriction Site
por: Stavros, Kallie M., et al.
Publicado: (2015)

Macromolecule adducts as biomarkers of exposure to environmental mutagens in human populations.
por: Ehrenberg, L, et al.
Publicado: (1996)

Real-time observation of DNA looping dynamics of Type IIE restriction enzymes NaeI and NarI
por: van den Broek, Bram, et al.
Publicado: (2006)

Cytotoxic and mutagenic effects of specific carcinogen-DNA adducts in diploid human fibroblasts.
por: McCormick, J J, et al.
Publicado: (1985)

Differences in conformational dynamics of [Pt(3)(HPTAB)](6+)–DNA adducts with various cross-linking modes
por: Zhu, Yanyan, et al.
Publicado: (2009)

Polyamines stimulate the formation of mutagenic 1,N(2)-propanodeoxyguanosine adducts from acetaldehyde
por: Theruvathu, Jacob A., et al.
Publicado: (2005)

Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway
por: Prorok, Paulina, et al.
Publicado: (2012)

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context
por: Rodríguez, Fabián A., et al.
Publicado: (2007)

Mutagenicity of Ochratoxin A and Its Hydroquinone Metabolite in the SupF Gene of the Mutation Reporter Plasmid Ps189
por: Akman, Steven A., et al.
Publicado: (2012)

A key interaction with RPA orients XPA in NER complexes
por: Topolska-Woś, Agnieszka M, et al.
Publicado: (2020)

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
por: Dexheimer, Thomas S., et al.
Publicado: (2008)

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ
por: Jha, Vikash, et al.
Publicado: (2016)

DNA adduct formation in the human nasal mucosa as a biomarker of exposure to environmental mutagens and carcinogens.
por: Flato, S, et al.
Publicado: (1996)

Correction: Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway
por: Prorok, Paulina, et al.
Publicado: (2013)

Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes
por: Jain, Nidhi, et al.
Publicado: (2009)

Detection and characterization of DNA adducts at the femtomole level by desorption ionization mass spectrometry.
por: Lay, J O, et al.
Publicado: (1993)

Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens.
por: Harris, C C
Publicado: (1985)

Effect of Increased Water Intake on Urinary DNA Adduct Levels and Mutagenicity in Smokers: A Randomized Study
por: Buendia Jimenez, Inmaculada, et al.
Publicado: (2015)

Following an environmental carcinogen N(2)-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase
por: Xu, Pingna, et al.
Publicado: (2007)

Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides
por: Guengerich, F. Peter, et al.
Publicado: (2021)

Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts
por: Sidorenko, Victoria S., et al.
Publicado: (2012)

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells
por: Lee, Hyun-Wook, et al.
Publicado: (2014)

Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation.
por: Wilson, V L, et al.
Publicado: (1993)

DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8–2′-deoxyguanosine adduct of the dietary mutagen IQ in human cells
por: Bose, Arindam, et al.
Publicado: (2015)

DNA adducts-chemical addons
por: Rajalakshmi, T. R., et al.
Publicado: (2015)

Alcohol, Aldehydes, Adducts and Airways
por: Sapkota, Muna, et al.
Publicado: (2015)

Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2
por: Lafrance-Vanasse, Julien, et al.
Publicado: (2012)

DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells
por: Klarer, Alden C., et al.
Publicado: (2012)

Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER
por: Lafrance-Vanasse, Julien, et al.
Publicado: (2013)

Structural and functional insights into the activation of the dual incision activity of UvrC, a key player in bacterial NER
por: Seck, Anna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mghtt37e7hqcme2jf5jevmk506