Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify both the binding affinity and the force-dependent threading intercalation ki...

Descripción completa

Detalles Bibliográficos
Autores principales: Almaqwashi, Ali A., Paramanathan, Thayaparan, Lincoln, Per, Rouzina, Ioulia, Westerlund, Fredrik, Williams, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191423/
https://www.ncbi.nlm.nih.gov/pubmed/25245944
http://dx.doi.org/10.1093/nar/gku859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191423/
https://www.ncbi.nlm.nih.gov/pubmed/25245944
http://dx.doi.org/10.1093/nar/gku859

Ejemplares similares