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Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease

Intrabodies offer attractive options for manipulating the protein misfolding that triggers neurodegenerative diseases. In Huntington's disease, where the expanded polyglutamine tract in the extreme N-terminal region of huntingtin exon1 misfolds, two lead intrabodies have been selected against a...

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Detalles Bibliográficos
Autores principales: Butler, D.C., Snyder-Keller, A., De Genst, E., Messer, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191446/
https://www.ncbi.nlm.nih.gov/pubmed/25301961
http://dx.doi.org/10.1093/protein/gzu041