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Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease
Intrabodies offer attractive options for manipulating the protein misfolding that triggers neurodegenerative diseases. In Huntington's disease, where the expanded polyglutamine tract in the extreme N-terminal region of huntingtin exon1 misfolds, two lead intrabodies have been selected against a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191446/ https://www.ncbi.nlm.nih.gov/pubmed/25301961 http://dx.doi.org/10.1093/protein/gzu041 |