Structure–Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz

[Image: see text] Cytochrome P450 2B6 (CYP2B6) is primarily responsible for the metabolism of the anti-HIV drug efavirenz (EFV). We set out to explore the molecular basis for CYP2B6 activity toward EFV by examining the metabolism of eight EFV analogues. cDNA-expressed CYP2B6 formed monooxygenated me...

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Detalles Bibliográficos
Autores principales: Cox, Philip M., Bumpus, Namandjé N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191608/
https://www.ncbi.nlm.nih.gov/pubmed/25309681
http://dx.doi.org/10.1021/ml500297n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191608/
https://www.ncbi.nlm.nih.gov/pubmed/25309681
http://dx.doi.org/10.1021/ml500297n

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