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Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration
Post-translational modification of proteins by small ubiquitin-related modifier (SUMO) is reversible and highly evolutionarily conserved from yeasts to humans. Unlike ubiquitination with a well-established role in protein degradation, sumoylation may alter protein function, activity, stability and s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191884/ https://www.ncbi.nlm.nih.gov/pubmed/25299344 http://dx.doi.org/10.1371/journal.pgen.1004579 |