Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms

Antisense oligonucleotides (ASOs) are most commonly designed to reduce targeted RNA via RNase H1-dependent degradation. In this paper we demonstrate that cellular proteins can compete for sites targeted by RNase H1-dependent ASOs. We further show that some ASOs designed to mediate RNase H1 cleavage...

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Detalles Bibliográficos
Autores principales: Vickers, Timothy A., Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191969/
https://www.ncbi.nlm.nih.gov/pubmed/25299183
http://dx.doi.org/10.1371/journal.pone.0108625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191969/
https://www.ncbi.nlm.nih.gov/pubmed/25299183
http://dx.doi.org/10.1371/journal.pone.0108625

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