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Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
The pluripotency factor Lin28 inhibits the biogenesis of the let-7 family of mammalian microRNAs(1–4). Lin28 is highly expressed in embryonic stem cells and has a fundamental role in regulation of development(5), glucose metabolism(6) and tissue regeneration(7). Alternatively, Lin28 overexpression i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192074/ https://www.ncbi.nlm.nih.gov/pubmed/25119025 http://dx.doi.org/10.1038/nature13553 |