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Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway

The pluripotency factor Lin28 inhibits the biogenesis of the let-7 family of mammalian microRNAs(1–4). Lin28 is highly expressed in embryonic stem cells and has a fundamental role in regulation of development(5), glucose metabolism(6) and tissue regeneration(7). Alternatively, Lin28 overexpression i...

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Detalles Bibliográficos
Autores principales:	Faehnle, Christopher R., Walleshauser, Jack, Joshua-Tor, Leemor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192074/ https://www.ncbi.nlm.nih.gov/pubmed/25119025 http://dx.doi.org/10.1038/nature13553

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