Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells

The mechanistic basis of obesity-associated intervertebral disc degeneration (IDD) is unclear. Aberrant expression of aggrecan and its degrading enzymes ADAMTS-4 and ADAMTS-5 is implicated in the development of IDD. Here, we investigated the effect of leptin, a hormone with increased circulating lev...

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Detalles Bibliográficos
Autores principales: Li, Zheng, Yu, Xin, Liang, Jinqian, Wu, William Ka Kei, Yu, Jun, Shen, Jianxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192299/
https://www.ncbi.nlm.nih.gov/pubmed/25299465
http://dx.doi.org/10.1371/journal.pone.0109595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192299/
https://www.ncbi.nlm.nih.gov/pubmed/25299465
http://dx.doi.org/10.1371/journal.pone.0109595

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