Morphine and Clonidine Combination Therapy Improves Therapeutic Window in Mice: Synergy in Antinociceptive but Not in Sedative or Cardiovascular Effects

Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflammatory pain. Unfortunately, opioid-related adverse effects such as respiratory depression, tolerance, physical dependence and addiction have led to an underutilization of these compounds for adequate...

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Detalles Bibliográficos
Autores principales: Stone, Laura S., German, Jonathan P., Kitto, Kelly F., Fairbanks, Carolyn A., Wilcox, George L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192360/
https://www.ncbi.nlm.nih.gov/pubmed/25299457
http://dx.doi.org/10.1371/journal.pone.0109903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192360/
https://www.ncbi.nlm.nih.gov/pubmed/25299457
http://dx.doi.org/10.1371/journal.pone.0109903

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