The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES

Protein aggregation into β-sheet-enriched amyloid fibrils is associated with an increasing number of human disorders. The adoption of such amyloid conformations seems to constitute a generic property of polypeptide chains. Therefore, during evolution, proteins have adopted negative design strategies...

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Detalles Bibliográficos
Autores principales: Sant'Anna, Ricardo, Braga, Carolina, Varejão, Nathalia, Pimenta, Karinne M., Graña-Montes, Ricardo, Alves, Aline, Cortines, Juliana, Cordeiro, Yraima, Ventura, Salvador, Foguel, Debora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192486/
https://www.ncbi.nlm.nih.gov/pubmed/25086037
http://dx.doi.org/10.1074/jbc.M114.563981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192486/
https://www.ncbi.nlm.nih.gov/pubmed/25086037
http://dx.doi.org/10.1074/jbc.M114.563981

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