Cargando…
Structural model of ubiquitin transfer onto an artificial RING finger as an E3 ligase
The artificial WSTF PHD_EL5 RING finger was designed via “α-helical region substitution”, and its structural model for the attachment of activated ubiquitin has been demonstrated. Chemical modifications of Cys residues, the circular dichroism spectra, and substrate-independent ubiquitination assays...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192618/ https://www.ncbi.nlm.nih.gov/pubmed/25300604 http://dx.doi.org/10.1038/srep06574 |