Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice

The effect of ApoE on NMDAR-dependent ERK/CREB signaling is isoform-dependent, and ApoE4 accelerates memory decline in ageing. However, this isoform-dependent function on neuronal signaling during ageing is unclear. In this study, we have examined NMDAR-associated ERK/CREB signal transduction in you...

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Detalles Bibliográficos
Autores principales: Yong, Shan-May, Lim, Mei-Li, Low, Chian-Ming, Wong, Boon-Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192620/
https://www.ncbi.nlm.nih.gov/pubmed/25301084
http://dx.doi.org/10.1038/srep06580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192620/
https://www.ncbi.nlm.nih.gov/pubmed/25301084
http://dx.doi.org/10.1038/srep06580

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