Development of a Functionally Minimized Mutant of the R3C Ligase Ribozyme Offers Insight into the Plausibility of the RNA World Hypothesis

The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme that lacks cytidine. Here, we attempted to modify the original R3C ribozyme (73 nucleotides) by reducing the number of nucleotides while maintaining the maximum possible catalytic efficiency. By partial...

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Detalles Bibliográficos
Autores principales: Kurihara, Eri, Uchida, Sayuri, Umehara, Takuya, Tamura, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192621/
https://www.ncbi.nlm.nih.gov/pubmed/25256424
http://dx.doi.org/10.3390/biology3030452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192621/
https://www.ncbi.nlm.nih.gov/pubmed/25256424
http://dx.doi.org/10.3390/biology3030452

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