mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features

mtDNA non-synonymous germ line variation (G10398A; p.A114T) has remained equivocal with least mechanistic understanding in showing an association with cancer. This has necessitated showing in-vitro how an over-expression within mitochondria of either of the variants produces higher intracellular ROS...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Rajnish Kumar, Srivastava, Archita, Kalaiarasan, Ponnusamy, Manvati, Siddharth, Chopra, Rupali, Bamezai, Rameshwar N. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192639/
https://www.ncbi.nlm.nih.gov/pubmed/25300428
http://dx.doi.org/10.1038/srep06571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192639/
https://www.ncbi.nlm.nih.gov/pubmed/25300428
http://dx.doi.org/10.1038/srep06571

Ejemplares similares