Cargando…

mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features

mtDNA non-synonymous germ line variation (G10398A; p.A114T) has remained equivocal with least mechanistic understanding in showing an association with cancer. This has necessitated showing in-vitro how an over-expression within mitochondria of either of the variants produces higher intracellular ROS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Rajnish Kumar, Srivastava, Archita, Kalaiarasan, Ponnusamy, Manvati, Siddharth, Chopra, Rupali, Bamezai, Rameshwar N. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192639/ https://www.ncbi.nlm.nih.gov/pubmed/25300428 http://dx.doi.org/10.1038/srep06571

Ejemplares similares

miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention
por: Srivastava, Niloo, et al.
Publicado: (2011)

Mapping of PARK2 and PACRG Overlapping Regulatory Region Reveals LD Structure and Functional Variants in Association with Leprosy in Unrelated Indian Population Groups
por: Chopra, Rupali, et al.
Publicado: (2013)

In Silico Screening, Genotyping, Molecular Dynamics Simulation and Activity Studies of SNPs in Pyruvate Kinase M2
por: Kalaiarasan, Ponnusamy, et al.
Publicado: (2015)

PARK2 and proinflammatory/anti-inflammatory cytokine gene interactions contribute to the susceptibility to leprosy: a case–control study of North Indian population
por: Chopra, Rupali, et al.
Publicado: (2014)

miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition
por: Manvati, Siddharth, et al.
Publicado: (2019)

MiR-101 Induces Senescence and Prevents Apoptosis in the Background of DNA Damage in MCF7 Cells
por: Manvati, Siddharth, et al.
Publicado: (2014)

Variation in germ line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
por: Freyer, Christoph, et al.
Publicado: (2012)

Replication of Type 2 Diabetes Candidate Genes Variations in Three Geographically Unrelated Indian Population Groups
por: Ali, Shafat, et al.
Publicado: (2013)

Hamiltonian energy as an efficient approach to identify the significant key regulators in biological networks
por: Haider, Shazia, et al.
Publicado: (2019)

Synergistic Combination of Gemcitabine and Dietary Molecule Induces Apoptosis in Pancreatic Cancer Cells and Down Regulates PKM2 Expression
por: Pandita, Archana, et al.
Publicado: (2014)

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
por: Quan, Yue, et al.
Publicado: (2020)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
por: Blumental-Perry, A., et al.
Publicado: (2020)

Inferring population structure and relationship using minimal independent evolutionary markers in Y-chromosome: a hybrid approach of recursive feature selection for hierarchical clustering
por: Srivastava, Amit Kumar, et al.
Publicado: (2014)

Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
por: Stenberg, Simon, et al.
Publicado: (2022)

Somatic mtDNA variation is an important component of Parkinson's disease
por: Coxhead, Jonathan, et al.
Publicado: (2016)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction
por: Zhang, Fenxi, et al.
Publicado: (2019)

Harnessing mtDNA variation to resolve ambiguity in ‘Redfish’ sold in Europe
por: Shum, Peter, et al.
Publicado: (2017)

Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology
por: Pal, Ranjana, et al.
Publicado: (2010)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c
por: Zempo, Hirofumi, et al.
Publicado: (2021)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
por: Iqbal, Mohd Askandar, et al.
Publicado: (2013)

Genetic diversity of Albanian goat breeds revealed by mtDNA sequence variation
por: Hoda, Anila, et al.
Publicado: (2014)

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number
por: Wachsmuth, Manja, et al.
Publicado: (2016)

No variation and low synonymous substitution rates in coral mtDNA despite high nuclear variation
por: Hellberg, Michael E
Publicado: (2006)

Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
por: Breton, Sophie, et al.
Publicado: (2011)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation
por: Fan, Zhen, et al.
Publicado: (2023)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells
por: Kuo, Chung-Wen, et al.
Publicado: (2017)

Keeping mtDNA in Shape between Generations
por: Stewart, James B., et al.
Publicado: (2014)

MtDNA-maintenance defects: syndromes and genes
por: Viscomi, Carlo, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ndjlef4ofar8fakv102udtigat