The Succinated Proteome of FH-Mutant Tumours

Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through va...

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Detalles Bibliográficos
Autores principales: Yang, Ming, Ternette, Nicola, Su, Huizhong, Dabiri, Raliat, Kessler, Benedikt M., Adam, Julie, Teh, Bin Tean, Pollard, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192685/
https://www.ncbi.nlm.nih.gov/pubmed/25105836
http://dx.doi.org/10.3390/metabo4030640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192685/
https://www.ncbi.nlm.nih.gov/pubmed/25105836
http://dx.doi.org/10.3390/metabo4030640

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