Cargando…

The Succinated Proteome of FH-Mutant Tumours

Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ming, Ternette, Nicola, Su, Huizhong, Dabiri, Raliat, Kessler, Benedikt M., Adam, Julie, Teh, Bin Tean, Pollard, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192685/ https://www.ncbi.nlm.nih.gov/pubmed/25105836 http://dx.doi.org/10.3390/metabo4030640

Ejemplares similares

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
por: Adam, Julie, et al.
Publicado: (2011)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
por: Ternette, Nicola, et al.
Publicado: (2013)

Novel Insights into FH-associated Disease are KEAPing the Lid on Oncogenic HIF Signalling
por: Adam, Julie, et al.
Publicado: (2011)

A quantitative label-free analysis of the extracellular proteome of human supraspinatus tendon reveals damage to the pericellular and elastic fibre niches in torn and aged tissue
por: Hakimi, Osnat, et al.
Publicado: (2017)

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection
por: Ternette, Nicola, et al.
Publicado: (2011)

Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
Publicado: (2023)

STAT5 is a potent negative regulator of T(FH) cell differentiation
por: Johnston, Robert J., et al.
Publicado: (2012)

Curcumin Elevates T(FH) Cells and Germinal Center B Cell Response for Antibody Production in Mice
por: Kim, Do-Hyun, et al.
Publicado: (2019)

Tox2 is required for the maintenance of GC T(FH) cells and the generation of memory T(FH) cells
por: Horiuchi, Shu, et al.
Publicado: (2021)

FH through the retrospectoscope
por: Thompson, Gilbert R.
Publicado: (2021)

Familial Hypercholesterolemia (FH) in Iran: Findings from the Four-Year FH Registry
por: Vaseghi, Golnaz, et al.
Publicado: (2021)

The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry
por: Alallaf, Faisal, et al.
Publicado: (2017)

Update on the FH01 study
por: Duffy, SW
Publicado: (2006)

A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa
por: Rivero, Francisco, et al.
Publicado: (2005)

Deep topographic proteomics of a human brain tumour
por: Davis, Simon, et al.
Publicado: (2023)

Pharmacogenetic aspects in familial hypercholesterolemia with the special focus on FH(Marburg) (FH p.W556R)
por: Schaefer, Juergen R., et al.
Publicado: (2012)

Know thy immune self and non‐self: Proteomics informs on the expanse of self and non‐self, and how and where they arise
por: Joyce, Sebastian, et al.
Publicado: (2021)

KIT mutation in a naïve succinate dehydrogenase‐deficient gastric GIST
por: Brcic, Iva, et al.
Publicado: (2019)

Succinate-treated macrophages attenuate dextran sodium sulfate colitis in mice
por: Park, I Seul, et al.
Publicado: (2021)

Cascade Screening for Familial Hypercholesterolemia (FH)
por: Ned, Renée M., et al.
Publicado: (2011)

Common Variable Immunodeficiency and Circulating T(FH)
por: Coraglia, Ana, et al.
Publicado: (2016)

Shortcomings on genetic testing of Familial hypercholesterolemia (FH) in India: Can we collaborate to establish Indian FH registry?
por: Reddy, Lakshmi Lavanya, et al.
Publicado: (2022)

T Cell Polarization toward T(H)2/T(FH)2 and T(H)17/T(FH)17 in Patients with IgG4-Related Disease
por: Grados, Aurélie, et al.
Publicado: (2017)

Glycerol as a substrate for aerobic succinate production in minimal medium with Corynebacterium glutamicum
por: Litsanov, Boris, et al.
Publicado: (2013)

Discovery of novel pyridine carboxamides with antifungal activity as potential succinate dehydrogenase inhibitors
por: Yan, Zhongzhong, et al.
Publicado: (2022)

Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding
por: Costa, Isabella, et al.
Publicado: (2014)

ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
por: Kastelein, John J.P., et al.
Publicado: (2015)

Microbial fuel cell-assisted utilization of glycerol for succinate production by mutant of Actinobacillus succinogenes
por: Zheng, Tianwen, et al.
Publicado: (2021)

Mechanisms of FH Protection Against Neovascular AMD
por: Borras, Céline, et al.
Publicado: (2020)

HIRA loss transforms FH-deficient cells
por: Valcarcel-Jimenez, Lorea, et al.
Publicado: (2022)

Dysregulation of T(FH)-B-T(RM) lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer
por: Cho, Jae-Won, et al.
Publicado: (2021)

Mutants of GABA Transaminase (POP2) Suppress the Severe Phenotype of succinic semialdehyde dehydrogenase (ssadh) Mutants in Arabidopsis
por: Ludewig, Frank, et al.
Publicado: (2008)

Activin A programs human T(FH) cell differentiation
por: Locci, Michela, et al.
Publicado: (2016)

The Genetic Spectrum of Familial Hypercholesterolemia (FH) in the Iranian Population
por: Fairoozy, R. H., et al.
Publicado: (2017)

Generation of TALEN-mediated FH knockout rat model
por: Yu, Dandan, et al.
Publicado: (2016)

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
por: Valcarcel-Jimenez, Lorea, et al.
Publicado: (2023)

The Prevalence and Diagnostic Ratio of Familial Hypercholesterolemia (FH) and Proportion of Acute Coronary Syndrome in Japanese FH Patients in a Healthcare Record Database Study
por: Teramoto, Tamio, et al.
Publicado: (2020)

Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization
por: Kollárová, Eva, et al.
Publicado: (2020)

Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours
por: Loughrey, Paul Benjamin, et al.
Publicado: (2022)

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
por: Khoronenkova, Svetlana V., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vo3a5tccio39oagmqbs74iucq1