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Activity artifacts in drug discovery and different facets of compound promiscuity
Compounds with apparent activity in a variety of assays might disable target proteins or produce false assay signals in the absence of specific interactions. In some instances, such effects are easy to detect, in others they are not. Observed promiscuity of compounds might be due to such non-specifi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000Research
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193391/ https://www.ncbi.nlm.nih.gov/pubmed/25339989 http://dx.doi.org/10.12688/f1000research.5426.1 |