Fragmentation Follows Structure: Top-Down Mass Spectrometry Elucidates the Topology of Engineered Cystine-Knot Miniproteins

Over the last decades the field of pharmaceutically relevant peptides has enormously expanded. Among them, several peptide families exist that contain three or more disulfide bonds. In this context, elucidation of the disulfide patterns is extremely important as these motifs are often prerequisites...

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Detalles Bibliográficos
Autores principales: Reinwarth, Michael, Avrutina, Olga, Fabritz, Sebastian, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193770/
https://www.ncbi.nlm.nih.gov/pubmed/25303319
http://dx.doi.org/10.1371/journal.pone.0108626