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Upregulation of SK3 and IK1 Channels Contributes to the Enhanced Endothelial Calcium Signaling and the Preserved Coronary Relaxation in Obese Zucker Rats
BACKGROUND AND AIMS: Endothelial small- and intermediate-conductance K(Ca) channels, SK3 and IK1, are key mediators in the endothelium-derived hyperpolarization and relaxation of vascular smooth muscle and also in the modulation of endothelial Ca(2+) signaling and nitric oxide (NO) release. Obesity...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193814/ https://www.ncbi.nlm.nih.gov/pubmed/25302606 http://dx.doi.org/10.1371/journal.pone.0109432 |