Upregulation of SK3 and IK1 Channels Contributes to the Enhanced Endothelial Calcium Signaling and the Preserved Coronary Relaxation in Obese Zucker Rats

BACKGROUND AND AIMS: Endothelial small- and intermediate-conductance K(Ca) channels, SK3 and IK1, are key mediators in the endothelium-derived hyperpolarization and relaxation of vascular smooth muscle and also in the modulation of endothelial Ca(2+) signaling and nitric oxide (NO) release. Obesity...

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Detalles Bibliográficos
Autores principales: Climent, Belén, Moreno, Laura, Martínez, Pilar, Contreras, Cristina, Sánchez, Ana, Pérez-Vizcaíno, Francisco, García-Sacristán, Albino, Rivera, Luis, Prieto, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193814/
https://www.ncbi.nlm.nih.gov/pubmed/25302606
http://dx.doi.org/10.1371/journal.pone.0109432

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